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HIV/AIDS
Research on HIV/AIDS described by G.B. Jacobs and colleagues
October 29th, 2008
"South Africa has the highest number of HIV-1-infected individuals in the world, with HIV-1 subtype C prevailing. However, HIV-1 subtype C accessory genes are rarely characterized in the country," scientists writing in the journal AIDS Research and Human Retroviruses report. "These genes are important for establishing viral pathogenesis. The Vif protein has been shown to counteract the antiretroviral activity of APOBEC3G/F cytidine deaminases. In this study an additional 50 HIV-1 vif sequences are characterized. These include 48 HIV-1 subtype C and 2 HIV-1 subtype B sequences. Highly conserved HIV-1 subtype C motifs are outlined. The previously identified RLRR...
Source: Vaccine Weekly (2008-10-29)
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