Immunization

Findings from College of Medicine provide new insights into immunization

Published in Vaccine Weekly, November 5th, 2008

"The role of innate immunity in the host response to Bacillus anthracis is poorly understood. We found that normal human serum contains an antitoxin mechanism that is capable of protecting macrophages in vitro from B. anthracis lethal toxin-mediated killing," researchers in the United States report.

"This protective activity was limited to defined amounts of toxin and was lost by heat treatment or serum dilution. Some person-to-person variation in the protective activity of serum was noted, especially with higher concentrations of lethal toxin. A similar protective activity was found in murine serum, though human serum consistently neutralized more toxin than did murine...

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Source: Vaccine Weekly (2008-11-05)

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