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Immunization
New immunization findings from Tohoku University described
November 5th, 2008
"Antineutrophil cytoplasmic antibodies ( ANCA) are autoantibodies, the detection of which in serum can be used in the diagnosis of Wegener's granulomatosis (WG). Proteinase 3 (PR3) is a major target antigen of ANCA in WG patients, and the interaction of PR3 ANCA with leukocytes causes a debilitating autoimmune disease," researchers in Sendai, Japan report. "The first signs and symptoms in WG patients are observed in the oral cavity, lungs, and kidneys. Human epithelial cells generally do not secrete proinflammatory cytokines upon stimulation with pathogen-associated molecular patterns ( PAMPs). In this study, anti- PR3 antibodies (Abs) and PR3 ANCA-containing sera from...
Source: Vaccine Weekly (2008-11-05)
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