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Immunization
Researchers from Leiden University report recent findings in immunization
November 5th, 2008
"To investigate whether protective immune responses can be induced in the absence of normal interleukin12/23/gamma interferon (IL-12/23/IFN-gamma) axis signaling, we vaccinated with the seasonal influenza virus subunit vaccine two patients with complete IL-12/23 receptor beta 1 (IL-12/23R beta 1) deficiencies, two patients with partial IFN-gamma receptor I (pIFN-gamma RI) deficiencies, and five healthy controls. Blood samples were analyzed before, 7 days after, and 28 days after vaccination," scientists writing in the journal Clinical and Vaccine Immunology report. "In most cases, antibody titers reached protective levels. Moreover, although T-cell responses in...
Source: Vaccine Weekly (2008-11-05)
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