Vaccine Weekly
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Immunization
Studies from J.S. Plested et al provide new data on immunization
November 5th, 2008
"The role of opsonophagocytosis (OP) in protection against meningococcal disease is controversial because patients with deficiencies in terminal complement proteins whose sera support OP but not bactericidal activity (BA) are at greatly increased risk of disease. We assayed complement-mediated BA and OP bactericidal activity in sera from 32 adults immunized with an outer membrane vesicle vaccine given alone or combined with an investigational recombinant protein, genome-derived neisserial antigen (GNA2132)," scientists writing in the journal Clinical and Vaccine Immunology report. "The sera were heat inactivated to remove internal complement activity, and BA was...
Source: Vaccine Weekly (2008-11-05)
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