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Phosphatase
New findings from Ohio State University in the area of phosphatase described
November 5th, 2008
According to a study from the United States, "Francisella tularensis is a facultative intracellullar pathogen and the etiologic agent of tularemia. It is capable of escape from macrophage phagosomes and replicates in the host cell cytosol." "Bacterial acid phosphatases are thought to play a major role in the virulence and intracellular survival of a number of intracellular pathogens. The goal of this study was to delete the four primary acid phosphatases (Acps) from Francisella novicida and examine the interactions of mutant strains with macrophages, as well as the virulence of these strains in mice. We constructed F. novicida mutants with various combinations of acp...
Source: Vaccine Weekly (2008-11-05)
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