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West Nile Virus
Georgetown University, Medical Department reports research in west nile virus
November 5th, 2008
According to recent research from the United States, "West Nile virus and dengue virus are mosquito-borne flaviviruses that cause a large number of human infections each year. No vaccines or chemotherapeutics are currently available." "These viruses encode a serine protease that is essential for polyprotein processing, a required step in the viral replication cycle. In this study, a high-throughput screening assay for the West Nile virus protease was employed to screen similar to 32,000 small-molecule compounds for identification of inhibitors. Lead inhibitor compounds with three distinct core chemical structures (1 to 3) were identified. In a secondary screening of...
Source: Vaccine Weekly (2008-11-05)
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