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DNA Vaccines
Data on DNA vaccines detailed by researchers at University of Otago
November 12th, 2008
Researchers detail in 'DNA fusion vaccines incorporating IL-23 or RANTES for use in immunization against influenza,' new data in dna. According to recent research published in the journal Vaccine, "The incorporation of RANTES or IL-23 into DNA vaccines may improve their immunogenicity by the recruitment and activation of dendritic cells. This may also select for a TH1 response counteracting the TH2 response which can predominate when a DNA vaccine is delivered by gene gun." "We have immunized mice with various DNA constructs encoding APR/8/34 influenza virus hemagglutinin (HA), either fused to or separate from, IL-23 or RANTES using a gene gun. Those immunized...
Source: Vaccine Weekly (2008-11-12)
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