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Vaccines
Research data from University College, Department of Microbiology update understanding of vaccines
November 12th, 2008
Researchers detail in 'Lactococcus lactis-expressing listeriolysin O (LLO) provides protection and specific CD8(+) T cells against Listeria monocytogenes in the murine infection model,' new data in vaccines. According to recent research from Cork, Ireland, "Lactococcus lactis has previously been proposed as a vaccine platform for the safe delivery of heterologous antigens. Here we utilized L. lactis as a live vector for expression of listeriolysin O (LLO), a major Listeria monocytogenes antigen and virulence factor." "A variety of plasmid constructs were designed to permit either constitutive or nisin-inducible expression of secreted or non-secreted LLO in L....
Source: Vaccine Weekly (2008-11-12)
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