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Aging
Research reports from L.M. Guerrettaz and co-authors provide new insights into aging
November 12th, 2008
According to recent research from the United States, "Aging is associated with an inability to mount protective antibody responses to vaccines and infectious agents. This decline is associated with acquisition of defects in multiple cellular compartments, including B cells." "While peripheral B-cell numbers do not decline with aging, the composition of the compartment appears to change, with loss of naive follicular B cells, accumulation of antigen-experienced cells, and alteration of the antibody repertoire. The underlying cause of this change is unknown. We tested the hypothesis that aging-associated repertoire changes can be attributed directly to decreased B...
Source: Vaccine Weekly (2008-11-12)
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