Immunization

Research on immunization described by S. Meronsudai and colleagues

Published in Vaccine Weekly, November 19th, 2008

"In the present study, we found that lipoteichoic acid (LTA) synergizes with glycosphingolipids to stimulate human blood cells to secrete cytokines. We employed globoside, kerasin, and lactosylceramide as representative neutral glycosphingolipids and mixed gangliosides GM(2) and GM(3) as representative acidic glycosphingolipids," scientists writing in the journal Clinical and Vaccine Immunology report.

"LTA and the glycosphingolipids enhanced cytokine secretion by human whole blood, peripheral blood mononuclear cells, and purified monocytes in a dose-dependent manner. The level of synergy ranged up to similar to 10-fold greater than the additive stimulation...

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Source: Vaccine Weekly (2008-11-19)

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