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Chimeric Proteins
Study results from Oklahoma State University update understanding of chimeric proteins
November 19th, 2008
According to recent research published in the journal Vaccine, "Mannheimia haemolytica is commonly identified in cattle with shipping fever pneumonia. Vaccines currently available do not provide complete protection against the disease." "In an effort to develop a vaccine that delivers the immunogenic regions of leukotoxin (LKT) A and the outer membrane protein (OMP) PlpE, a total of four chimeric proteins were constructed. Mice were subcutaneously immunized with 25, 50 and 75 mu g quantities of each chimeric protein. The specificity of the immune response was confirmed by Western blot analysis and enzyme-linked immunosorbent assays (ELISA). Moreover, the...
Source: Vaccine Weekly (2008-11-19)
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