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Malaria Vaccines
Studies from University of Copenhagen yield new data on malaria vaccines
November 19th, 2008
According to a study from Copenhagen, Denmark, "Immunogenicity testing of Plasmodium falciparum antigens being considered as malaria vaccine candidates was undertaken in rabbits. The antigens compared were recombinant baculovirus MSP-1(19) and five Pichia pastoris candidates, including two versions of MSP-1(19), AMA-1 (domains I and II), AMA-1 + MSP-1(19), and fused AMA-1/MSP-1(19)." "Animals were immunized with equimolar amounts of each antigen, formulated in Montanide ISA720. The specificities and titers of antibodies were compared using immunofluorescence assays and enzyme-linked immunosorbent assay (ELISA). The antiparasite activity of immunoglobulin G (IgG) in in...
Source: Vaccine Weekly (2008-11-19)
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