Rockefeller University Press
How HIV vaccine might have increased odds of infection
Published in Vaccine Weekly, November 19th, 2008
In September 2007, a phase II HIV-1 vaccine trial was abruptly halted when researchers found that the vaccine may have promoted, rather than prevented, HIV infection. A new study by a team of researchers at the Montpellier Institute of Molecular Genetics in France shows how the vaccine could have enhanced HIV infection. The study, lead by Matthieu Perreau, will be published online on November 3 of the Journal of Experimental Medicine.
The HIV-1 vaccine used in Merck's STEP trial relied on a weakened form of a common cold virus, Adenovirus 5 (Ad5), to carry bits of HIV into the body. Those bits would presumably trigger the immune system to fight off later infection with...
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Source: Vaccine Weekly (2008-11-19)
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