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Cancer Vaccines
Research in the area of cancer vaccines reported from University of California
November 26th, 2008
"Therapeutic vaccination of B cell lymphoma patients with tumor-specific Ig (idiotype, or Id) chemically coupled to the immunogenic foreign carrier protein keyhole limpet hemocyanin (KLH) using glutaraldehyde has shown promising results in early clinical trials, and phase III trials are underway. However, glutaraldehyde Id-KLH vaccines fail to elicit anti-Id immune and clinical responses in many patients, possibly because glutaraldehyde reacts with lysine, cysteine, tyrosine, and histidine residues, damaging critical immunogenic epitopes," scientists writing in the Journal of Immunology report. "A sulfhydryl-based tumor Ag-carrier protein conjugation system using...
Source: Vaccine Weekly (2008-11-26)
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