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Vaccine Weekly

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Influenza



Studies from University of Massachusetts provide new data on influenza



November 26th, 2008

"Among 17 HLA-A2-positive healthy adults, CD8(+) T-cell responses against an HLA-A2-restricted matrix protein 1 (M1) epitope increased after immunization with trivalent inactivated influenza vaccine (TIV) in two individuals," researchers in the United States report.

"The presence of M1 in TIV was confirmed by Western blotting. T-cell cytotoxicity assays showed that TIV is processed and the epitope is presented by antigen-presenting cells to an M1 epitope-specific CD8(+) T-cell line for specific lysis," wrote M. Terajima and colleagues, University of Massachusetts.

The researchers concluded: "These data show that TIV, which is formulated to contain...


Source: Vaccine Weekly (2008-11-26)

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