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Vaccines
Scientists at University of Maryland, Medical Department detail research in vaccines
November 26th, 2008
"Francisella tularensis (Ft), the causative agent of tularemia, elicits a potent inflammatory response early in infection, yet persists within host macrophages and can be lethal if left unchecked. We report in this study that Ft live vaccine strain (LVS) infection of murine macrophages; induced TLR2-dependent expression of alternative activation markers that followed the appearance of classically activated markers," scientists in the United States report. "Intraperitoneal infection with Ft LVS also resulted in induction of alternatively activated macrophages (AA-M phi). Induction of AA-M phi by treatment of cells with rIL-4 or by infection with Ft LVS promoted...
Source: Vaccine Weekly (2008-11-26)
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