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Beth Israel Deaconess Medical Center



T cell-based HIV vaccine candidate demonstrates positive results



November 26th, 2008

The question of whether or not to continue to pursue the development of T-cell-based HIV-1 vaccines has been a source of controversy following last year's widely publicized failure of the field's most promising candidate, a vaccine developed by Merck known as V520.

Now a study led by investigators at Beth Israel Deaconess Medical Center (BIDMC) provides the proof-of-concept that a T-cell-based strategy remains a viable course to follow.

Described in today's dvance On-line Publication of Nature, the study showed that an improved regimen using two distinct adenovirus vectors – rAd26 prime/rAd5 boost – and expressing the simian immunodeficiency virus...


Source: Vaccine Weekly (2008-11-26)

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