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Drug Resistance
Researchers from University of Maryland provide details of new studies and findings in the area of drug resistance
November 26th, 2008
According to recent research published in the journal Infection and Immunity, "Live attenuated bacterial strains expressing heterologous antigens represent an attractive vaccine development strategy. However, the use of drug resistance genes for the selection of expression plasmids introduced into live vectors poses theoretical health risks." "Therefore, we developed a novel approach for plasmid selection based on immunity to the antimicrobial peptide microcin H47 (MccH47). Two expression plasmids encoding the reporter green fluorescent protein (GFPuv) were constructed; selection markers comprised either mchI, conferring immunity to MccH47 (pGEN222I), or bla...
Source: Vaccine Weekly (2008-11-26)
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