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Influenza
Research from Rutgers University broadens understanding of influenza
December 3rd, 2008
"Influenza A viruses are responsible for seasonal epidemics and high mortality pandemics. A major function of the viral NS1A protein, a virulence factor, is the inhibition of the production of IFN-beta mRNA and other antiviral mRNAs," scientists in the United States report. "The NS1A protein of the human influenza A/Udorn/72 (Ud) virus inhibits the production of these antiviral mRNAs by binding the cellular 30-kDa subunit of the cleavage and polyadenylation specificity factor (CPSF30), which is required for the 3' end processing of all cellular pre-mRNAs. Here we report the 1.95-angstrom resolution X-ray crystal structure of the complex formed between the second and...
Source: Vaccine Weekly (2008-12-03)
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