Immunization

Scientists at University of Antwerp target immunization

Published in Vaccine Weekly, December 3rd, 2008

According to recent research from Antwerp, Belgium, "The trematode Fasciola hepatica (Fa. he.) is a common parasite of human and livestock. The hemoglobin (Hb) of Fa. he., a potential immunogen, was chosen for characterization in the search for an effective vaccine."

"Characterization of trematode Hbs show that they are intracellular single-domain globins with the following remarkable features: (1) Fa. he. expresses two Hb isoforms that differ at two amino acid sites (F1: 119Y/123Q; F2: 119F/123L). Both isoforms are monoacetylated at their N-termini; (2) the genes coding for Fa. he. and Paramphistomum epiclitum (Pa. ep.) Hbs are interrupted by two introns at the...

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Source: Vaccine Weekly (2008-12-03)

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