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Vaccine Weekly

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Melanoma



Research on melanoma described by scientists at National Institutes of Health



December 10th, 2008

"Immunotherapy for melanoma has undergone significant change since the first attempts to treat patients with high dose IL-2. Herein, strategies to boost patient antitumor immunity through vaccination, treatment with agents that augment host immunity, and adoptive cell transfer will be discussed," scientists in the United States report.

"The first two strategies have yielded only limited clinical success, but adoptive cell transfer therapy, particularly following a lymphodepleting, preconditioning regimen has resulted in objective response rates approaching 50%. For a number of reasons, lymphodepletion appears to be critical for maintenance of circulating antitumor T...


Source: Vaccine Weekly (2008-12-10)

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