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Allergies
Research data from Medical University of Vienna update understanding of allergies
December 10th, 2008
According to recent research published in the Journal of Immunology, "The recognition of conformational epitopes on respiratory allergens by IgE Abs is a key event in allergic inflammation. We report a molecular strategy for the conversion of allergens into vaccines with reduced allergenic activity, which is based on the reassembly of non-IgE-reactive fragments in the form of mosaic proteins." "This evolution process is exemplified for timothy grass pollen-derived Ph1 p 2, a major allergen for more than 200 million allergic patients. In a first step, the allergen was disrupted into peptide fragments lacking IgE reactivity. cDNAs coding for these peptides were...
Source: Vaccine Weekly (2008-12-10)
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