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Hepatitis C Virus
Scientists at Emory University, Emory Vaccine Center detail research in hepatitis C virus
December 17th, 2008
According to a study from the United States, "Mechanisms by which hepatitis C virus (HCV) evades cellular immunity to establish persistence in chronically infected individuals are not clear. Mutations in human leukocyte antigen (HLA) class I-restricted epitopes targeted by CD8(+) T cells are associated with persistence, but the extent to which these mutations affect viral fitness is not fully understood." "Previous work showed that the HCV quasispecies in a persistently infected chimpanzee accumulated multiple mutations in numerous class I epitopes over a period of 7 years. During the acute phase of infection, one representative epitope in the C-terminal region of the...
Source: Vaccine Weekly (2008-12-17)
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