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Vaccine Weekly

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Immunization



Studies from National Institutes of Health in the area of immunization published



December 17th, 2008

Researchers detail in 'Heterosubtypic immunity to influenza A virus: where do we stand,' new data in immunization. "Influenza A virus (IAV) strains are denoted by the subtype of their hemagglutinin (HA) and neuraminidase (NA) virion surface proteins. Major changes in HA subtype among strains circulating in humans are referred to as 'antigenic shift'," scientists in the United States report.

"Antigenic shift can occur by two means: direct transmission of a zoonotic strain to humans or through reshuffling of the segmented genome in cells co-infected with animal and human strains. The lack of circulating anti-HA antibodies in human populations to a novel IAV results in...


Source: Vaccine Weekly (2008-12-17)

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