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Vaccine Weekly

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Vaccines



New vaccines study results reported from St. Jude Children's Research Hospital, Department of Infectious Diseases



December 17th, 2008

Current study results from the report, 'Modulation of adaptive immunity by different adjuvant-antigen combinations in mice lacking Nod2,' have been published. "The mechanisms underlying adjuvant effects are under renewed scrutiny because of the enormous implications for vaccine development. Additionally, new low-toxicity adjuvants are sought to enhance vaccine formulations," scientists in the United States report.

"Muramyl dipeptide (MDP) is a component of the peptidoglycan polymer and was shown to be an active but low-toxicity component of complete Freund's adjuvant, a powerful adjuvant composed of mycobacteria lysates in an oil emulsion. MDP activates cells primarily...


Source: Vaccine Weekly (2008-12-17)

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