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DNA Vaccines
Study findings from University of Ghent provide new insights into DNA vaccines
December 17th, 2008
According to recent research from Merelbeke, Belgium, "We previously demonstrated that intradermal (ID) delivery of plasmid DNA encoding the porcine granulocyte-macrophage colony-stimulating factor (GM-CSF) 7 days before DNA vaccination enhances both cellular and Immoral responses in pigs." "In the present work, we studied the effect of the GM-CSF gene on antigen-presenting cells (APC) in pigs. We demonstrated that ID delivery of this gene significantly increased the number of epidermal CD1(+) cells (Langerhans' cells, skin dendritic cells) at the injection site at day 7. This was accompanied by an enhanced percentage of APC at the immune induction site following DNA...
Source: Vaccine Weekly (2008-12-17)
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