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Simian Immunodeficiency Virus
Study findings from University of Tokyo provide new insights into simian immunodeficiency virus
December 24th, 2008
"Gag-specific cytotoxic T lymphocytes (CTLs) exert strong suppressive pressure on human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication. However, it has remained unclear whether they can actually contain primary viral replication," investigators in Tokyo, Japan report. "Recent trials of prophylactic vaccines inducing virus-specific T-cell responses have indicated their potential to confer resistance against primary SIV replication in rhesus macaques, while the immunological determinant for this vaccine-based viral control has not been elucidated thus far. Here we present evidence implicating Gag-specific CTLs as responsible for the...
Source: Vaccine Weekly (2008-12-24)
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