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Falciparum Malaria Cell Biology



Data from Food & Drug Administration advance knowledge in falciparum malaria cell biology



December 24th, 2008

Investigators publish new data in the report 'Centrins, cell cycle regulation proteins in human malaria parasite Plasmodium falciparum.' "Molecules and cellular mechanisms that regulate the process of cell division in malaria parasites remain poorly understood. In this study we isolate and characterize the four Plasmodium falciparum centrins (PfCENs) and, by growth complementation studies, provide evidence for their involvement in cell division," researchers in the United States report.

"Centrins are cytoskeleton proteins with key roles in cell division, including centrosome duplication, and possess four Ca(2+)-binding EF hand domains. By means of phylogenetic...


Source: Vaccine Weekly (2008-12-24)

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