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Extraordinary immune cells may hold the key to managing HIV

Published in Vaccine Weekly, December 24th, 2008

People who manage to control HIV on their own are providing scientists with valuable information about how the immune system eliminates virus-infected cells. A new study, published in the December 4th issue of Immunity, a Cell Press publication, identifies specific characteristics of the immune cells that successfully destroy HIV-infected cells and may drive strategies for developing the next generation of HIV vaccines and therapies.

Long-term nonprogressors (LTNPs) or elite controllers are rare individuals who are able to contain HIV for many years without any type of antiretroviral therapy. "Direct and indirect lines of evidence in humans and animal models suggest...

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