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Hepatitis C Virus
Study data from A.M. Vandermeeren et al provide new insights into hepatitis C virus
December 24th, 2008
According to recent research from Madrid, Spain, "To identify the subcellular forms and biochemical events induced in human cells after HCV polyprotein expression, we have used a robust cell culture system based on vaccinia virus (VACV) that efficiently expresses in infected cells the structural and nonstructural proteins of HCV from genotype 1b (VT7-HCV7.9). As determined by confocal microscopy, HCV proteins expressed from VT7-HCV7.9 localize largely in a globular-like distribution pattern in the cytoplasm, with some proteins co-localizing with the endoplasmic reticulum ( ER) and mitochondria." "As examined by electron microscopy, HCV proteins induced formation of...
Source: Vaccine Weekly (2008-12-24)
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