Adenovirus

Study findings from University of Alabama broaden understanding of adenovirus

Published in Vaccine Weekly, December 24th, 2008

"Despite the many potential advantages of Ad vectors for vaccine application, the full utility of current Ad vaccines may be limited by the host anti-vector immune response. Direct incorporation of antigens into the adenovirus capsid offers a new and exciting approach for vaccination strategies; this strategy exploits the inherent antigenicity of the Ad vector," scientists in the United States report.

"Critical to exploiting Ad in this new context is the placement of antigenic epitopes within the major Ad capsid protein, hexon. In our current study we illustrate that we have the capability to place a range of antigenic epitopes within Ad5 capsid protein hexon...

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Source: Vaccine Weekly (2008-12-24)

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