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Smallpox
New findings in smallpox described from University of Pennsylvania, Medical Department
December 24th, 2008
According to recent research from the United States, "Variola virus, the causative agent of smallpox, is a potential bioweapon. The development of new antiviral compounds for smallpox prophylaxis and treatment is critical, especially because the virus can acquire resistance to the drugs that are currently available." "We have identified novel small chemical inhibitors that target DNA synthesis of vaccinia, the prototypical poxvirus. Robotic high-throughput screening of 49663 compounds and follow-up studies identified very potent inhibitors of vaccinia DNA synthesis, with IC50 values as low as 0.5 mc M. Cell-based assays showed that 16 inhibitors effectively blocked...
Source: Vaccine Weekly (2008-12-24)
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