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Vaccinia Virus
New vaccinia virus findings from R. Izmailyan and co-authors described
December 24th, 2008
According to recent research published in the Journal of Virology, "The vaccinia virus WR53.5L/ F14.5L gene encodes a small conserved protein that was not detected previously. However, additional proteomic analyses of different vaccinia virus isolates and strains revealed that the WR53.5 protein was incorporated into intracellular mature virus (IMV)." "The WR53.5 protein contains a putative N-terminal transmembrane region and a short C-terminal region. Protease digestion removed the C terminus of WR53.5 protein from IMV particles, suggesting a similar topology to that of the IMV type II transmembrane protein. We generated a recombinant vaccinia virus, vi53.5L,...
Source: Vaccine Weekly (2008-12-24)
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