Anthrax

Research on anthrax published by D. Tross et al

Published in Vaccine Weekly, December 24th, 2008

"Adding synthetic oligodeoxynucleotides containing unmethylated CpG motifs to Anthrax vaccine adsorbed (AVA, the licensed human vaccine) increases the speed and magnitude of the resultant Ab response. Ab titers persist in the protective range for > 1 year, significantly longer than in animals vaccinated with AVA alone," investigators in the United States report.

"Unexpectedly, a majority of mice immunized with CpG-adjuvanted AVA maintained resistance to anthrax infection even after their Ab titers had declined into the subprotective range. The survival of these animals was mediated by the de novo production of protective Abs by high affinity memory B cells...

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Source: Vaccine Weekly (2008-12-24)

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