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Vaccinia Virus
Study findings on vaccinia virus are outlined in reports from Medical College of Wisconsin, Medical College
December 24th, 2008
"The previously unstudied vaccinia virus gene I2L is conserved in all orthopoxviruses. We show here that the 8-kDa I2 protein is expressed at late times of infection, is tightly associated with membranes, and is encapsidated in mature virions," scientists writing in the Journal of Virology report. "We have generated a recombinant virus in which I2 expression is dependent upon the inclusion of tetracycline in the culture medium. In the absence of I2, the biochemical events of the viral life cycle progress normally, and virion morphogenesis culminates in the production of mature virions. However, these virions show an similar to 400-fold reduction in specific...
Source: Vaccine Weekly (2008-12-24)
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