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DNA Vaccines
Reports summarize DNA vaccines research from National Institutes of Health
December 24th, 2008
"Previously, combination DNA/nonreplicating adenovirus (Ad)-or poxvirus-vectored vaccines have strongly protected against SHIV89.6P, DNAs expressing cytokines have modulated immunity elicited by DNA vaccines, and replication-competent Ad-recombinant priming and protein boosting has strongly protected against simian immunodeficiency virus (SIV) challenge. Here we evaluated a vaccine strategy composed of these promising components," scientists in the United States report. "Seven rhesus macaques per group were primed twice with multigenic SIV plasmid DNA with or without interleukin-12 (IL-12) DNA or IL-15 DNA. After a multigenic replicating Ad-SIV immunization, all groups...
Source: Vaccine Weekly (2008-12-24)
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