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Falciparum Malaria Vaccines
Research results from Biomedical Primate Research Center, Department of Parasitology update knowledge of falciparum malaria vaccines
December 31st, 2008
New research, 'Production, quality control, stability and pharmacotoxicity of cGMP-produced Plasmodium falciparum AMA1 FVO strain ectodomain expressed in Pichia pastoris,' is the subject of a report. According to recent research published in the journal Vaccine, "Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is a leading asexual blood stage vaccine candidate for malaria. In preparation for clinical trials, PfAMA1 ectodomain (amino acid 25-545, FVO strain) was produced in Pichia pastoris by 35L scale fed batch fermentation under current Good Manufacturing Practice (cGMP)." "Fermentation was followed by a three-step chromatographic...
Source: Vaccine Weekly (2008-12-31)
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