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Clinical Trial Research
New clinical trial research from University of California described
December 31st, 2008
"New pre-clinical trials in AD mouse models may help to develop novel immunogen-adjuvant configurations with the potential to avoid the adverse responses that occurred during the clinical trials with AN-1792 vaccine formulation. Recently, we have pursued an alternative immunization strategy that replaces QS21 the Th1 type adjuvant used in the AN-1792 clinical trial with a molecular adjuvant, mannan that can promote a Th2-polarized immune response through interactions with mannose-binding and CD35/CD21 receptors of the innate immune system," scientists in the United States report. "Previously we established that immunization of wild-type mice with mannan-A beta(28)...
Source: Vaccine Weekly (2008-12-31)
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