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Lupus Vaccines
Studies from University of Florida have provided new information about lupus vaccines
December 31st, 2008
A new study, 'Defective B-cell response to T-dependent immunization in lupus-prone mice,' is now available. According to a study from the United States, "Lupus anti-nuclear Ab show the characteristics of Ag-driven T-cell-dependent (TD) humoral responses. If autoAg elicit the same response as exogenous Ag, lupus should enhance humoral responses to immunization." "Blunted responses to various immunizations have, however, been reported in a significant portion of lupus patients. In this study, we show that lupus-prone C57BL/6.Sle1.Sle2.Sle3 (B6.TC) mice produce significantly less Ab in response to TD immunization than congenic controls, while producing significantly more...
Source: Vaccine Weekly (2008-12-31)
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