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Vaccines
New vaccines data have been reported by researchers at University of London
December 31st, 2008
A report, 'Cytoplasmic delivery of antigens, by Bacillus subtilis enhances Th1 responses,' is newly published data in Vaccine. According to a study from Egham, the United Kingdom, "Endospores of the Gram-positive bacterium, Bacillus subtilis, have been used successfully for delivery of antigens where the immunogen is expressed on the spore surface. In this work the spore has been engineered to deliver antigens to the cytoplasm of macrophages by expressing listeriolysin O (LLO) or a derivative, LLO(L461T), that is stable at neutral pH, from the B. subtilis vegetative cell." "Following phagocytosis spores were shown to germinate in the phagosome enabling secretion...
Source: Vaccine Weekly (2008-12-31)
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