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Cancer Vaccines
Researchers from Pennsylvania State University provide details of new studies and findings in the area of cancer vaccines
January 7th, 2009
According to recent research from the United States, "T cell large granular lymphocyte (T-LGL) leukemia features a clonal expansion of antigen-primed, competent, cytotoxic T lymphocytes (CTL). To systematically understand signaling components that determine the survival of CTL in T-LGL leukemia, we constructed a T-LGL survival signaling network by integrating the signaling pathways involved in normal CTL activation and the known deregulations of survival signaling in leukemic T-LGL." "This network was subsequently translated into a predictive, discrete, dynamic model. Our model suggests that the persistence of IL-15 and PDGF is sufficient to reproduce all known...
Source: Vaccine Weekly (2009-01-07)
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