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Vaccine Weekly

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Fusion Proteins



Research results from D. Liu and colleagues update understanding of fusion proteins



January 7th, 2009

"The terminal degradation product (C3d) of mammalian complement component C3 plays an important role in modulation of the adaptive immune response through the interaction with complement receptor type 2 (CR2) on B cells. In this study, the gene fragment coding for the complement protein C3d (chC3d) from Roman chicken was cloned and expressed as a fusion protein for its application in the vaccine study of chicken, and for in vitro experiments," scientists in Shandong, People's Republic of China report.

"The chC3d fragment strengthened B-cell responses when complexed with antigen. Three potential vaccine construct units were engineered to contain two, four and six copies...


Source: Vaccine Weekly (2009-01-07)

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