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HIV/AIDS
Recent studies from University of Wisconsin add new data to HIV/AIDS
January 7th, 2009
According to a study from the United States, "An effective AIDS vaccine will need to protect against globally diverse isolates of HIV. To address this issue in macaques, we administered a live-attenuated simian immunodeficiency virus (SIV) vaccine and challenged with a highly pathogenic heterologous isolate." "Vaccinees reduced viral replication by similar to 2 logs between weeks 2-32 (P <= 0.049) postchallenge. Remarkably, vaccinees expressing MHC-I (MHC class I) alleles previously associated with viral control completely suppressed acute phase replication of the challenge virus, implicating CD8(+) T cells in this control. Furthermore, transient depletion of...
Source: Vaccine Weekly (2009-01-07)
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