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Vaccine Weekly

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Life Sciences



National Institutes of Health publishes research in life sciences



January 7th, 2009

According to recent research published in the journal Proceedings of the National Academy of Sciences of the United States of America, "Toll-like receptors (TLRs) may need to cooperate with each other to be effective in detecting imminent infection and trigger immune responses. understanding is still limited about the intracellular mechanism of this cooperation."

"We found that when certain TLRs are involved, dendritic cells (DCs) establish unidirectional intracellular cross-talk, in which the MyD88-independent TRIF-dependent pathway amplifies the MyD88-dependent DC function through a JNK-dependent mechanism. The amplified MyD88-dependent DC function determines...


Source: Vaccine Weekly (2009-01-07)

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