Vaccinia Virus
Reports from S.S. Zheng et al highlight recent research in vaccinia virus
Published in Vaccine Weekly, January 7th, 2009
According to recent research published in the journal RNA - a Publication of the RNA Society, "RNA guanine-N7 methyltransferase catalyzes the third step of eukaryal mRNA capping, the transfer of a methyl group from AdoMet to GpppRNA to form m 7 GpppRNA. Mutational and crystallographic analyses of cellular and poxvirus cap methyltransferases have yielded a coherent picture of a conserved active site and determinants of substrate specificity."
"Models of the Michaelis complex suggest a direct in-line mechanism of methyl transfer. Because no protein contacts to the guanine-N7 nucleophile, the AdoMet methyl carbon (C epsilon) or the AdoHcy sulfur (S delta) leaving...
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Source: Vaccine Weekly (2009-01-07)
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