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Norwegian Institute of Public Health
Fractional dose of scarce meningitis vaccine may be effective in outbreak control
January 7th, 2009
One fifth of the standard dose of a commonly used meningitis vaccine may be as effective as using the full dose. This new finding should allow scarce vaccine resources to be stretched further, especially during epidemics in Africa. In a study initiated by the Norwegian Institute of Public Health, together with Epicentre (the research arm of Doctors Without Borders/Medecins Sans Frontieres), and Mbarara University of Science and Technology in Uganda, immune responses in patients receiving smaller doses of a meningitis vaccine were found to be comparable to a full dose. In 2004, a randomized clinical trial of 750 healthy volunteers (2-19 years old)...
Source: Vaccine Weekly (2009-01-07)
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