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Purdue University



Biologists spy close-up view of poliovirus linked to host cell receptor



January 7th, 2009

Researchers from Purdue and Stony Brook universities have determined the precise atomic-scale structure of the poliovirus attached to key receptor molecules in human host cells and also have taken a vital snapshot of processes leading to infection.

The virus binds to a receptor on the cell to form a single complex.

"This structure had been predicted, but the predictions were not as accurate as we had thought," said Michael Rossmann, Purdue's Hanley Distinguished Professor of Biological Sciences. "What we have now is the real structure, as opposed to a prediction of the receptor molecule. We also have a much higher resolution view of the complex of...


Source: Vaccine Weekly (2009-01-07)

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