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Immunization
Research reports on immunization from A.H. Gradman and colleagues provide new insights
January 7th, 2009
"Immunologic approaches to renin-angiotensin-aldosterone system (RAAS) inhibition have been studied for more than 50 years. In animal models, vaccination against renin was effective but resulted in fatal autoimmune renal disease; vaccines directed at small peptides including angiotensin I and II and a segment of the AT 1 receptor reduced blood pressure (BP) without causing autoimmune disease," scientists writing in the journal Current Hypertension Reports report. "In humans, angiotensin I vaccination did not reduce BP. More promising is the AngQb vaccine, which uses an immunization technology involving conjugation of angiotensin II to virus-like particles. In a...
Source: Vaccine Weekly (2009-01-07)
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