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Vaccine Weekly

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Human Papillomavirus



Researchers from Brigham and Women's Hospital detail new studies and findings in the area of human papillomavirus



January 14th, 2009

According to a study from the United States, "We report the case of a young woman who developed a subcutaneous granulomatous response after administration of the quadrivalent human papillomavirus vaccine. The inciting agent was most likely an aluminum adjuvant, which previously has been reported to be associated with a granulomatous response after administration of other vaccines."

"Histologically, the lesion consisted of a necrotic/necrobiotic center surrounded by palisading epithelioid histiocytes closely resembling deep granuloma annulare or rheumatoid nodule. The histiocytes contained abundant intracytoplasmic violaceous/gray granular material. An ammonium...


Source: Vaccine Weekly (2009-01-14)

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